![]() ![]() "We are excited about the increasing recognition of SemaPhore's differentiating features, as we are seeing growing interest by pharma and biotech companies in our technology," commented Covadonga Pañeda, Ph.D., Altamira's Chief Operating Officer. This latter feature is essential for those therapeutic indications where repeated administrations are required. In addition, SemaPhore is able to protect its RNA cargo from degradation without triggering an immune response (non-immunogenic). SemaPhore nanoparticles are characterized by a favorable tolerability profile while solving some of the inherent issues observed with LNPs: namely, delivering their cargo extra-hepatically, and efficiently promoting cellular uptake as well as endosomal release. These limitations include predominant uptake by the liver following systemic administration, limited stability (requiring storage at ultralow temperatures), LNP-related toxicity and immunogenicity as well as poor endosomal release within cells (reported at only 1-2% of the payload).,īased on SemaPhore's unique features, Altamira sees strong promise for its application in the field of mRNA delivery. While LNPs have been effectively and widely used especially for delivery of mRNA vaccines, they have certain limitations which prevent or restrict their use in various promising areas of therapeutic mRNA application. ![]() Since the project started in early 2017 there have been a number of success stories across the country where candidates have been supplied with iPads and training.According to fresh data from the Beacon RNA database by Hanson Wade, the number of mRNA vaccines and therapeutics under development has now grown to more than 840, of which 356 are using some sort of LNP for delivery. Access social media such as YouTube, Kindle and other E-books,.Register with Doctors’ surgeries online, make medical appointments and order prescriptions,.Order shopping online when unable to get out,.Obtain cheaper energy, insurance, phone and broadband deals online,.Use local and national online government advice and application systems, such as Dorset for You and Gov.UK.Access Veterans information, such as the Branch website, Facebook, RNA Central Office or Area website,.Able to communicate easily with family and friends via Skype, FaceTime, or Messenger, etc.Some of the benefits of being online include: People who aren’t able to make full use of the internet are thought to be £1000 worse off than those that do have access. Isolated shipmates can benefit from modern technology to help them connect with friends and family and regain some of their independence. Further information, and how to apply are available here. Potential candidates can apply for an iPad by contacting Sarah Clewes, the Project Manager at RNA Central Office. They may have a family member who does email for them or other service – this does not preclude from them getting their own iPad. Potential candidates should not currently be on-line themselves. Widows of Naval veterans who would have qualified are also entitled to apply. A naval veteran not in the RNA qualifies and could be sponsored by their local RNA branch. There is no requirement regarding length of service, reason for discharge, pension etc. To qualify for an iPad Veterans must be aged over 65, and have served in the RN, RM, Reserves, WRNS, QARNNS, RNXS etc. The project is funded by the Aged Veterans Fund, and managed by RNA Central Office. Project Semaphore is an RNA initiative to get ‘digitally isolated shipmates’ online by providing those eligible with an iPad and training on how to use it. Aka “Get veteran Jacks and Jennys an iPad” ![]()
0 Comments
Leave a Reply. |